ABSTRACT
The problem of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains highly relevant. Objective. To analyze clinical and laboratory characteristics of patients with moderate COVID-19. Materials and methods. This retrospective study included 132 patients with moderate COVID-19 treated in the Republican Immunological Center of the Republic of Dagestan between July and December 2020. The sample included 69 males and 63 females with a mean age of 52.4 ± 5.9 years. Results. The most common clinical manifestations included fever, fatigue, dry cough, and headache. Many participants had increased erythrocyte sedimentation rate (ESR);some patients had leukopenia, lymphopenia, and thrombocytopenia. Biochemical testing demonstrated mild alterations in the levels of C-reactive protein (CRP), ferritin, glucose, activity of liver enzymes (alanine aminotransferase, as-partate aminotransferase), fibrinogen, and D-dimer. These alterations were primarily observed in COVID-19 patients with CT-2 changes in their lung tissue. One-third of participant had lesions in lungs upon discharge. ECG changes (rhythm and conduction abnormalities) were detected in 15.9% of patients with concomitant cardiovascular diseases. Conclusion. COVID-19 patients with persistent clinical, laboratory, or radiological changes upon their discharge from hospital, as well patients with changes on ECG, require careful follow-up to assess their long-term outcomes. © 2021, Dynasty Publishing House. All rights reserved.
ABSTRACT
The study deals with the clinical and laboratory manifestations of mild and moderate forms of COVID-19 depending on the gestational period in 69 pregnant women aged 18 to 41 (28.5 +/- 6.9), hospitalized with a "COVID-19" diagnosis. The patients under study exhibited no significant differences in clinical symptoms and main laboratory data, including coagulogram (p >0.05) throughout three trimesters of pregnancy. The severity of COVID-19 in pregnant women most likely depends on the presence of concomitant extragenital pathology and burdened gynecological history (pathology of previous pregnancies and childbirth) rather than on gestational period (pathology of previous pregnancies and childbirth), since more often these pathologies occurred in pregnant women with moderate COVID-19. The research showed that women in all three trimesters of pregnancy showed a significant increase (p <0.05) in C-reactive protein, a specific marker of inflammation, the findings, obtained in the 2nd and 3rd trimesters of pregnancy (26.7 +/- 21.97 and 32.7 +/- 26.5 mg/l) insignificantly (p1-3 = 0.056, p2-3 = 0.231) exceeded those, observed in the 1st trimester (14.8 +/- 26.9). Copyright (C) 2013 - All Rights Reserved - Pharmacophore